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Nonoxynol-9 is a common ingredient of most vaginal and anal lubricants due to its spermicidal properties. A 2004 study found that over a six-month period, the typical-use failure rates for five nonoxynol-9 vaginal contraceptives (film, suppository, and gels at three different concentrations) ranged from 10% to 20%.
Early symptoms include intoxication, vomiting and abdominal pain. [1] Later symptoms may include a decreased level of consciousness, headache, and seizures. [1] Long term outcomes may include kidney failure and brain damage. [1] Toxicity and death may occur after drinking even in a small amount [1] as ethylene glycol is more toxic than other diols.
Industrially it is a railroad tie preservative and used in the surfacing of roads. [6] Coal tar was listed as a known human carcinogen in the first Report on Carcinogens from the U.S. Federal Government, issued in 1980. [7] Coal tar was discovered circa 1665 and used for medical purposes as early as the 1800s.
Effects on animals Effects on animals p-Chlorocresol has low to moderate acute oral toxicity in rats and mice, with a median lethal dose (LD50) of 1830 mg/kg in male Wistar rats. [25] It has also been shown to be corrosive to the skin of New Zealand White rabbits when applied dermally, and an irritant to rabbit eyes. [ 26 ]
Chronic solvent-induced encephalopathy (CSE) is a condition induced by long-term exposure to organic solvents, often—but not always—in the workplace, that lead to a wide variety of persisting sensorimotor polyneuropathies and neurobehavioral deficits even after solvent exposure has been removed.
That changed in 1980, and since then, tons of other brands of lubricant have flooded the market. Many people having sex (including solo sex) know that lube is a must-have in their pleasure tool kit.
Olestra was approved by the Food and Drug Administration for use as a food additive in 1996 and was initially used in potato chips under the WOW brand by Frito Lay.In 1998, the first year olestra products were marketed nationally after the FDA's Food Advisory Committee confirmed a judgment it made two years earlier, sales were over $400 million.
Chlorine gas poisoning is an illness resulting from the effects of exposure to chlorine beyond the threshold limit value.Acute chlorine gas poisoning primarily affects the respiratory system, causing difficulty breathing, cough, irritation of the eyes, nose, and throat, and sometimes skin irritation.