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Tetracycline, sold under various brand names, is an antibiotic in the tetracyclines family of medications, ... Tetracyclines have a broad spectrum of antibiotic action.
Tetracycline resistance is often due to the acquisition of new genes, which code for energy-dependent efflux of tetracyclines or for a protein that protects bacterial ribosomes from the action of tetracyclines. Furthermore, a limited number of bacteria acquire resistance to tetracyclines by mutations.
Tetracycline-controlled transcriptional activation is a method of inducible gene expression where transcription is reversibly turned on or off in the presence of the antibiotic tetracycline or one of its derivatives (e.g. doxycycline).
Demeclocycline inhibits the renal action of antidiuretic hormone by interfering with the intracellular second messenger cascade (specifically, inhibiting adenylyl cyclase activation) after the hormone binds to vasopressin V 2 receptors in the kidney. [18] [19] [20] Exactly how demeclocycline does this has yet to be elucidated, however. [20]
The overall structure of TetR can be broken down into two DNA-binding domains (one per monomer) and a regulatory core, which is responsible for tetracycline recognition and dimerization. TetR dimerizes by making hydrophobic contacts within the regulatory core. There is a binding cavity for tetracycline in the outer helices of the regulatory domain.
For example, chloramphenicol and tetracyclines are antagonists to penicillins. However, this can vary depending on the species of bacteria. [74] In general, combinations of a bacteriostatic antibiotic and bactericidal antibiotic are antagonistic. [71] [72]
Minocycline, like most tetracyclines, becomes dangerous past its expiration date. [54] While most prescription drugs lose potency after their expiration dates, tetracyclines are known to become toxic over time. Expired tetracyclines can cause serious damage to the kidney due to the formation of a degradation product, anhydro-4-epitetracycline. [54]
Pages in category "Tetracycline antibiotics" The following 20 pages are in this category, out of 20 total. This list may not reflect recent changes. ...