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Over two million prescriptions for paroxetine were written for children or adolescents in the US in 2002. [29]Funded by SmithKline Beecham, the acute phase of study 329 was an eight-week, double-blind, randomized clinical trial conducted in 12 university or hospital psychiatric departments in the United States and Canada between 1994 and 1997.
The study authors' note: "emotional blunting is reported by nearly half of depressed patients on antidepressants and that it appears to be common to all monoaminergic antidepressants not only SSRIs". Additionally, they note: "The OQuESA scores are highly correlated with the HAD depression score; emotional blunting cannot be described simply as ...
The data collected through formal (typically self-report) measurement (like the PHQ-9 for depression [3]) has been used to enhance the accuracy of clinical assessments, provide a basis for treatment planning, deliver an objective methodology for tracking treatment progress, alert therapists with clinically proven guidelines to get refractory cases back on track, help prevent hospitalizations ...
A recent example of such case study is by Gorgulu et al. (2021), who studied patients from the Department of Psychiatry in Trakya University Hospital. The study consisted of a group of 38 patients, aged 18–65, who met the diagnostic category for unipolar mania as they had experienced a minimum of four manic episodes and were in the euthymic ...
Depressed patients are at increased risk of type 2 diabetes, cardiovascular disease and suicide. Within the next twenty years depression is expected to become the second leading cause of disability worldwide and the leading cause in high-income nations, including the United States.
Mayberg is known in particular for her work delineating abnormal brain function in patients with major depression using functional neuroimaging. [1] [2] This work led to the first pilot study of deep brain stimulation (DBS), a reversible method of selective modulation of a specific brain circuit, for patients with treatment-resistant depression ...