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  2. cAMP-dependent pathway - Wikipedia

    en.wikipedia.org/wiki/CAMP-dependent_pathway

    The pathway may also be deactivated downstream by directly inhibiting adenylyl cyclase or dephosphorylating the proteins phosphorylated by PKA. Molecules that inhibit the cAMP pathway include: cAMP phosphodiesterase converts cAMP into AMP by breaking the phosphodiester bond, in turn reducing the cAMP levels

  3. Protein kinase A - Wikipedia

    en.wikipedia.org/wiki/Protein_kinase_A

    In cell biology, protein kinase A (PKA) is a family of serine-threonine kinase [1] whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP-dependent protein kinase (EC 2.7.11.11). PKA has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.

  4. Cyclic adenosine monophosphate - Wikipedia

    en.wikipedia.org/wiki/Cyclic_adenosine_monophosphate

    cAMP represented in three ways Adenosine triphosphate. Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger, or cellular signal occurring within cells, that is important in many biological processes. cAMP is a derivative of adenosine triphosphate (ATP) and used for intracellular signal transduction in many different organisms ...

  5. Biochemical cascade - Wikipedia

    en.wikipedia.org/wiki/Biochemical_cascade

    The cAMP/PKA signaling pathway leads to sperm cells capacitation; however, adenylyl cyclase in sperm cells is different from the somatic cells. Adenylyl cyclase in spermatozoon does not recognize G proteins , so it is stimulated by bicarbonate and Ca 2+ ions.

  6. PRKAR1A - Wikipedia

    en.wikipedia.org/wiki/PRKAR1A

    cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase A , which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes ...

  7. Crosstalk (biology) - Wikipedia

    en.wikipedia.org/wiki/Crosstalk_(biology)

    One example of crosstalk between proteins in a signalling pathway can be seen with cyclic adenosine monophosphate's (cAMP) role in regulating cell proliferation by interacting with the mitogen-activated protein (MAP) kinase pathway. cAMP is a compound synthesized in cells by adenylate cyclase in response to a variety of extracellular signals.

  8. Gs alpha subunit - Wikipedia

    en.wikipedia.org/wiki/Gs_alpha_subunit

    Although each GTP-bound G s α can activate only one adenylyl cyclase enzyme, amplification of the signal occurs because one receptor can activate multiple copies of G s while that receptor remains bound to its activating agonist, and each G s α-bound adenylyl cyclase enzyme can generate substantial cAMP to activate many copies of PKA. [8]

  9. PRKAR2A - Wikipedia

    en.wikipedia.org/wiki/PRKAR2A

    cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent Protein Kinase, more commonly called Protein Kinase A (PKA), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two ...