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The symbiotic relationship between a host and its microbiota is under laboratory research for how it may shape the immune system of mammals. [ 52 ] [ 53 ] In many animals, the immune system and microbiota may engage in "cross-talk" by exchanging chemical signals, which may enable the microbiota to influence immune reactivity and targeting. [ 54 ]
Kidneys of various animals show evidence of evolutionary adaptation and have long been studied in ecophysiology and comparative physiology. Kidney morphology, often indexed as the relative medullary thickness, is associated with habitat aridity among species of mammals [ 49 ] and diet (e.g., carnivores have only long loops of Henle).