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Roth's spots, also known as Litten spots or the Litten sign, [1] are non-specific red lesions with white or pale centres, seen on the retina of the eye and although traditionally associated with infective endocarditis, can occur in a number of other conditions including hypertension, diabetes, collagen vascular disease, extreme hypoxia, leukemia and HIV.
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Other signs of endocarditis include Roth's spots and Janeway lesions. The latter, which also occur on the palms and soles, can be differentiated from Osler's nodes because they are non-tender. [3] Osler's nodes can also be seen in Systemic lupus erythematosus; Marantic endocarditis; Disseminated gonococcal infection; Distal to infected arterial ...
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Initially, posting classified ads was offered as a free service. The site quickly grew in popularity and started attracting many visitors that posted more and more classified ads. At the end of 1999, Van Mullem sold the website Marktplaats.nl for ƒ 600,000 -ca. €273,000- to the company Het Goed from Emmeloord , a Dutch national chain of ...
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Litten's sign is a clinical sign in which cotton wool spots are seen on fundoscopic examination of the retina in patients with infective endocarditis. [ 1 ] The sign is named after Moritz Litten .
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