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For amebic dysentery a multi-prong approach must be used, starting with one of: metronidazole 500–750 mg three times a day for 5–10 days; tinidazole 2g once a day for 3 days is an alternative to metronidazole; Doses for children are calculated by body weight and a pharmacist should be consulted for help.
In all three cases, the drug therapy resulted in clearance of the infection, defined as negative results through an O&P exam, in all but 1-2 patients. [4] A 1979 study of 27 patients treated with dehydroemetine and various other drugs suggested all drug combinations were successful at treating amoebic liver abscesses. [5]
Antisialagogues are drugs or substances that decrease the flow rate of saliva and their effect is opposite to that of sialagogues. [1] Their origin may be both natural and synthetic. Anticholinergics generally have antisialagogue effects, and most produce some level of sedation , both being advantageous in surgical procedures .
Paromomycin is an antimicrobial used to treat a number of parasitic infections including amebiasis, giardiasis, leishmaniasis, and tapeworm infection. [3] It is a first-line treatment for amebiasis or giardiasis during pregnancy. [3]
Diloxanide furoate destroys trophozoites of E. histolytica and prevents amoebic cyst formation. [9] The exact mechanism of diloxanide is unknown. [ 10 ] Diloxanide is structurally related to chloramphenicol and may act in a similar fashion by disrupting the ribosome [ 5 ]
Tinidazole, sold under the brand name Tindamax among others, is a medication used against protozoan infections.It is widely known throughout Europe and the developing world as a treatment for a variety of anaerobic amoebic and bacterial infections.
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