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Orally administered rifampicin results in peak plasma concentrations in about 2–4 hours. 4-Aminosalicylic acid (another antituberculosis drug) significantly reduces absorption of rifampicin, [56] and peak concentrations may be lower. If these two drugs must be used concurrently, they must be given separately, with an interval of 8 to 12 hours ...
Isoniazid/rifampicin, also known as isoniazid/rifampin, is a medication used to treat tuberculosis. [1] It is a fixed dose combination of isoniazid and rifampicin (rifampin). [1] It is used together with other antituberculosis medication. [1] It is taken by mouth. [1] It is on the World Health Organization's List of Essential Medicines. [2]
Side effects are those of the underlying medications. [1] These may include poor coordination, loss of appetite, nausea, joint pain, feeling tired, and numbness. [2] Severe side effects include liver problems. [3] Use in those under the age of 15 may not be appropriate. [3] It is unclear if use in pregnancy is safe for the baby. [3]
The rifamycin group includes the classic rifamycin drugs as well as the rifamycin derivatives rifampicin (or rifampin), rifabutin, rifapentine, rifalazil and rifaximin. Rifamycin, sold under the trade name Aemcolo, is approved in the United States for treatment of travelers' diarrhea in some circumstances.
Side effects are those of the underlying medications. [1] Pyridoxine may be used to decrease the risk of numbness. [2] It is not recommended in people with liver problems or severe kidney problems. [3] Use may not be suitable in children. [1] It is unclear if use during pregnancy is safe. [3]
[2] [4] [7] It is generally (but not always) less preferred than the tetracycline doxycycline. [4] [7] Minocycline is also used for the treatment of acne and rheumatoid arthritis. [7] [3] It is taken by mouth or applied to the skin. [4] [3] Common side effects include nausea, diarrhea, dizziness, allergic reactions, and kidney problems. [4]
However, in the United States, clofazimine is considered an orphan drug, is unavailable in pharmacies, and its use in the treatment of MAC is overseen by the Food and Drug Administration. [5] It is taken orally. [1] Common side effects include abdominal pain, diarrhea, itchiness, dry skin, and change in skin color. [1]
Serious side effects may include liver problems or Clostridioides difficile associated diarrhea. [3] It is unclear if use during pregnancy is safe. [3] Rifapentine is in the rifamycin family of medication and works by blocking DNA-dependent RNA polymerase. [3] Rifapentine was approved for medical use in the United States in 1998. [2]