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A one pill, once a day combination therapy has been introduced in South Africa for as little as $10 per patient per month. [78] One 2013 study estimated an overall cost savings to ART therapy in South Africa given reduced transmission. [79] In the United States, new on-patent regimens can cost up to $28,500 per patient, per year. [80] [81]
According to the US CDC definition, one has AIDS if he/she is infected with HIV and present with one of the following: A CD4+ T-cell count below 200 cells/μl (or a CD4+ T-cell percentage of total lymphocytes of less than 14%) OR. he/she has one of the following defining illnesses: Candidiasis of bronchi, trachea, or lungs; Candidiasis esophageal
After a spiked replication of HIV, the viral load and CD4 T cell count drops back down. Symptoms of acute HIV infection include fever, chills, rash, night sweats, muscle aches, and swollen lymph nodes. Acute symptoms occur usually 2–4 weeks after initial HIV infection and can last between a few days and several weeks [3]
HIV is a retrovirus that primarily infects components of the human immune system such as CD4 + T cells, macrophages and dendritic cells. It directly and indirectly destroys CD4 + T cells. [88] HIV is a member of the genus Lentivirus, [89] part of the family Retroviridae. [90] Lentiviruses share many morphological and biological characteristics.
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Nucleic-acid-based tests amplify and detect one or more of several target sequences located in specific HIV genes, such as HIV-I GAG, HIV-II GAG, HIV-env, or the HIV-pol. [32] [33] Since these tests are relatively expensive, the blood is screened by first pooling some 8–24 samples and testing these together; if the pool tests positive, each ...
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