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[3] [4] It was introduced as a sedative and medication for morning sickness without having been tested on pregnant women. [5] While initially deemed to be safe in pregnancy, concerns regarding birth defects were noted in 1961, and the medication was removed from the market in Europe that year. [3] [6]
Doxylamine is used in the combination drug pyridoxine/doxylamine to treat morning sickness (nausea and vomiting of pregnancy). [19] [20] [21] It is the only medication approved by the United States Food and Drug Administration for the treatment of morning sickness. [19] [20]
Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine hydrochloride (vitamin B 6) and doxylamine succinate.It is generally used for nausea and vomiting of pregnancy (morning sickness); even though its efficacy has not been proven and subsequent research has led to the removal of recommendations in medical journals.
Researchers at Chemie Grünenthal found that thalidomide was a particularly effective antiemetic that had an inhibitory effect on morning sickness. [44] On 1 October 1957, the company launched thalidomide and began marketing it under the trade name Contergan. [45] [46] It was proclaimed a "wonder drug" for insomnia, coughs, colds and headaches ...
"My sickness started early on – from the second I knew I was pregnant, before I even took a test," Ms McIntyre told BBC News. "Around about six weeks, the morning sickness really kicked in ...
In a breakthrough discovery, scientists have identified the cause of pregnancy morning sickness, raising hope for a possible cure. Researchers found that a hormone exposed to pregnant women ...