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Reproductive toxicants may adversely affect sexual function, ovarian failure, fertility as well as causing developmental toxicity in the offspring. [2] [3] Lowered effective fertility related to reproductive toxicity relates to both male and female effects alike and is reflected in decreased sperm counts, semen quality and ovarian failure.
Developmental toxicity is any developmental malformation that is caused by the toxicity of a chemical or pathogen. It is the structural or functional alteration, reversible or irreversible, which interferes with homeostasis, normal growth, differentiation, development or behavior.
The Standard for Exchange of Nonclinical Data (SEND) is an implementation of the CDISC Standard Data Tabulation Model (SDTM) for nonclinical studies, which specifies a way to present nonclinical data in a consistent format. These types of studies are related to animal testing conducted during drug development.
Teratology is the study of abnormalities of physiological development in organisms during their life span. It is a sub-discipline in medical genetics which focuses on the classification of congenital abnormalities in dysmorphology caused by teratogens and also in pharmacology and toxicology.
Reproductive Toxicology is a peer-reviewed journal published bimonthly by Elsevier which focuses on the effects of toxic substances on the reproductive system. The journal was established in 1987 and is affiliated with the European Teratology Society. According to the Journal Citation Reports, the journal has a 2023 impact factor of 3.3. [1]
This tool assesses medical and reproductive history and history of cancer among first-degree relatives to determine a woman's risk of developing invasive breast cancer within five years and up to ...
Ovarian culture is an in-vitro process that allows for the investigation of the development, toxicology and pathology of the ovary. [1] This technique can also be used to study possible applications of fertility treatments e.g. isolating oocytes from primordial ovarian follicles that could be used for fertilisation.
A study examining different types of alcohol found that higher consumption of liquor and beer was associated with increased visceral fat in adults. This makes it even more important to moderate ...