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Metformin is a pleiotropic drug, with extensive off-target activity beyond its antidiabetic effect. Much of this has been attributed to its action on AMPK, although other mechanisms have been proposed. [ 214 ][ 215 ] Metformin has been studied for its effects on multiple other conditions, including:
Pioglitazone/metformin is indicated as an adjunct to diet and exercise: [medical citation needed] To improve glycemic control in patients with type 2 diabetes, or; For patients who are already treated with a separate combination of pioglitazone and metformin, For patients whose diabetes is not adequately controlled with metformin alone, or
1 kg⋅m 2 ⋅s −3. The volt-ampere (SI symbol: VA, [1] sometimes V⋅A or V A) is the unit of measurement for apparent power in an electrical circuit. It is the product of the root mean square voltage (in volts) and the root mean square current (in amperes). [2] Volt-amperes are usually used for analyzing alternating current (AC) circuits.
The Centennial Light is an incandescent light bulb recognized as the oldest known continuously operating light bulb. It was first illuminated in 1901, and has only been turned off a few brief times since. It is located at 4550 East Avenue, Livermore, California, and is open to public viewing. [1] Due to its longevity, the bulb has been noted by ...
Harvesting lightning energy. Since the late 1980s, there have been several attempts to investigate the possibility of harvesting lightning energy. A single bolt of lightning carries a relatively large amount of energy (approximately 7 gigajoules [1] or about the energy stored in 38 Imperial gallons or 172 litres of gasoline).
Metal-halide lamp. Metal halide lamp bulb (type /O with arc tube shield) A common spectrum of metal halide lamps in North America. Metal halide floodlights at a baseball field. Metal halide lamps were invented by Charles Proteus Steinmetz in 1912 and are now used in almost every city in the world. A metal-halide lamp is an electrical lamp that ...
Cracking your neck too hard or too often could lead to: Pinched nerve. Stroke. Blood clot. Osteoarthritis. While these are low risk, the risk is higher for individuals who have conditions such as ...
White LEDs quickly matched and overtook the efficacy of standard incandescent lighting systems. In 2002, Lumileds made five-watt LEDs available with luminous efficacy of 18–22 lumens per watt (lm/W). For comparison, a conventional incandescent light bulb of 60–100 watts emits around 15 lm/W, and standard fluorescent lights emit up to 100 lm/W.