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Myasthenia gravis (MG) is a long-term neuromuscular junction disease that leads to varying degrees of skeletal muscle weakness. [1] The most commonly affected muscles are those of the eyes, face, and swallowing. [1][5] It can result in double vision, drooping eyelids, and difficulties in talking and walking. [1]
Myasthenia gravis is caused by autoantibodies to the postsynaptic acetylcholine receptors. Lambert–Eaton myasthenic syndrome (LEMS) is a rare autoimmune disorder characterized by muscle weakness of the limbs. It is also known as myasthenic syndrome, Eaton–Lambert syndrome, and when related to cancer, carcinomatous myopathy.
Neurology. Congenital myasthenic syndrome (CMS) is an inherited neuromuscular disorder caused by defects of several types at the neuromuscular junction. The effects of the disease are similar to Lambert-Eaton Syndrome and myasthenia gravis, the difference being that CMS is not an autoimmune disorder. There are only 600 known family cases of ...
Transient neonatal myasthenia gravis, i.e., TNMG (also termed neonatal myasthenia gravis [1]), and its more severe form, fetal acetylcholine receptor inactivation syndrome (i.e., FARIS), is one of the various types of myasthenia gravis (i.e., MG). [2] MG is an autoimmune disease in which individuals form antibodies that circulate in their blood ...
Neuromuscular junction. The neuromuscular junction is a specialized synapse between a neuron and the muscle it innervates. It allows efferent signals from the nervous system to contract muscle fibers causing them to contract. In vertebrates, the neuromuscular junction is always excitatory, therefore to stop contraction of the muscle, inhibition ...
Cholinergic crisis. Cholinergic crisis. Other names. Cholinergic toxicity, cholinergic poisoning, SLUDGE syndrome. A cholinergic crisis is an over-stimulation at a neuromuscular junction due to an excess of acetylcholine (ACh), [1] as a result of the inactivity of the AChE enzyme, which normally breaks down acetylcholine.
Glycogen storage disease type V. Poor physical or mental health due to prolonged delay in diagnosis, misdiagnosis, or having been given inappropriate exercise advice. Rare complications include rhabdomyolysis with myoglobinuria requiring hospitalization, transient muscle contracture, and compartment syndrome. Genetic testing (preferred), muscle ...
Ptosis of the left eyelid (unilateral ptosis). A headshot daguerreotype of an unidentified male, by William Bell in 1852. Ptosis, also known as blepharoptosis, [1] is a drooping or falling of the upper eyelid. This condition is sometimes called "lazy eye", but that term normally refers to the condition amblyopia.
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