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Schwann cells or neurolemmocytes (named after German physiologist Theodor Schwann) are the principal glia of the peripheral nervous system (PNS). Glial cells function to support neurons and in the PNS, also include satellite cells, olfactory ensheathing cells, enteric glia and glia that reside at sensory nerve endings, such as the Pacinian corpuscle.
Perisynaptic schwann cells (also known as Terminal schwann cells or Teloglia) are neuroglia found at the Neuromuscular junction (NMJ) with known functions in synaptic transmission, synaptogenesis, and nerve regeneration. [1] These cells share a common ancestor with both Myelinating and Non-Myelinating Schwann Cells called Neural Crest cells.
Neurilemma (also known as neurolemma, sheath of Schwann, or Schwann's sheath) [1] is the outermost nucleated cytoplasmic layer of Schwann cells (also called neurilemmocytes) that surrounds the axon of the neuron. It forms the outermost layer of the nerve fiber in the peripheral nervous system. [2]
The nonmyelinating Schwann cells are a subgroup of the Schwann cells characterized by not forming myelin. [1]The group of nonmyelinating Schwann cells includes the terminal Schwann cells, present at neuromuscular junctions, the Schwann cells of Remak fibers (also called Remak Schwann cells) and the Schwann cells associated to sensory structures, like tactile corpuscles and lamellar corpuscles.
In the peripheral nervous system (PNS), glial cells known as Schwann cells (or also as neuri-lemmocytes) promote repair. After axonal injury, Schwann cells regress to an earlier developmental state to encourage regrowth of the axon. This difference between the CNS and the PNS, raises hopes for the regeneration of nervous tissue in the CNS.
When a peripheral nerve is damaged, Schwann cells alter their morphology, behavior and proliferation to become involved in Wallerian degeneration and Bungner bands. [38] In Wallerian degeneration, Schwann cells grow in ordered columns along the endoneurial tube, creating a band of Bungner (boB) that protects and preserves the endoneurial channel.
These layers are generally uniform and continuous, but due to imperfect nature of the process by which Schwann cells wrap the nerve axon, this wrapping process can sometimes leave behind small pockets of residual cytoplasm displaced to the periphery during the formation of the myelin sheath. These pockets, or "incisures", can subdivide the ...
The first is oligodendrocyte, which can be found in the mammalian Central Nervous System (CNS). The second is Schwann cells, which are found in the Peripheral Nervous System (PNS). Myelination of axons by these Schwann cells are essential for normal nerve function. Peripheral nerves rely on communication between axons and Schwaan cells. [2]
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