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Androgen replacement therapy (ART), often referred to as testosterone replacement therapy (TRT), is a form of hormone therapy in which androgens, often testosterone, are supplemented or replaced. It typically involves the administration of testosterone through injections, skin creams, patches, gels, pills, or subcutaneous pellets.
It is recommended that individuals with prostate cancer should not use the medication. [9] It can cause harm to the baby if used during pregnancy or breastfeeding. [9] Testosterone is in the androgen family of medications. [9] Testosterone was first isolated in 1935, and approved for medical use in 1939.
One study concluded that long-term testosterone replacement therapy (TRT) in middle-aged men with late-onset hypogonadism (LOH) and metabolic syndrome (MS) led to a significant increase in both vertebral and femoral bone mineral density (BMD) after 36 months of treatment, as measured by dual-energy x-ray absorptiometry. The TRT treatment was ...
Although promoted as a way of customizing treatment, hormone therapy does not require customization; [38] the use of testing to determine the number of hormones administered could result in the dose being higher than the minimum recommended level to alleviate symptoms, [2] [8] or the administration of unnecessary hormones to asymptomatic women ...
[2] [27] In addition, while a 60 mg dose has no effect on testosterone levels in men, this dose does measurably increase testosterone levels in prepubertal boys and women. [27] The oral bioavailability of testosterone in young women after a single 25 mg dose was found to be 3.6 ± 2.5%. [ 29 ]
Anabolic steroid use and testosterone replacement therapy (TRT) have been found to cause testicular atrophy through similar mechanisms. [2] [1] [17] Anabolic steroids and TRT are both used (either by prescription or illicitly) to mimic the effects of testosterone produced by the body, such as building muscle and maintaining sex drive.