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While not recommended historically, starting allopurinol during an attack of gout appears to be safe. [8] [9] In those already on the medication, it should be continued even during an acute gout attack. [8] [6] While use during pregnancy does not appear to result in harm, this use has not been well studied. [1]
Levels that cannot be brought below 6.0 mg/dL while attacks continue indicates refractory gout. [68] While historically it is not recommended to start allopurinol during an acute attack of gout, this practice appears acceptable. [69] Allopurinol blocks uric acid production, and is the most commonly used agent. [20]
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Periods when gout symptoms are more severe are called gout flares or gout attacks. A gout flare comes on suddenly, and symptoms are often intense. ... while purines are found in every cell of the ...
Uricosurics are often used in the treatment of gout, a disease in which uric acid crystals form deposits in the joints. By decreasing plasma uric acid levels, help dissolve these crystals, while limiting the formation of new ones. However, the increased uric acid levels in urine can contribute to kidney stones.
Allopurinol: The American College of Rheumatology guidelines for the management of gout recommend HLA-B*58:01 screening before allopurinol treatment. This is provided in many medical centers in Taiwan, Hong Kong, Thailand, and Mainland China.
Unless high blood levels of uric acid are determined in a clinical laboratory, hyperuricemia may not cause noticeable symptoms in most people. [5] Development of gout – which is a painful, short-term disorder – is the most common consequence of hyperuricemia, which causes deposition of uric acid crystals usually in joints of the extremities, but may also induce formation of kidney stones ...
] The safety trial was conducted in over 6,000 patients with gout treated with either febuxostat or allopurinol. The primary outcome was a combination of heart-related death, non-deadly heart attack, non-deadly stroke, and a condition of inadequate blood supply to the heart requiring urgent surgery.