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Deoxyribonuclease II (DNase II) is also known as acid deoxyribonuclease because it has optimal activity in the low pH environment of lysosomes where it is typically found in higher eukaryotes. Some forms of recombinant DNase II display a high level of activity in low pH in the absence of divalent metal ions, similar to eukaryotic DNase II. [7]
Deoxyribonuclease I (usually called DNase I), is an endonuclease of the DNase family coded by the human gene DNASE1. [5] DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides.
Type I site-specific deoxyribonuclease (EC 3.1.21.3, type I restriction enzyme, deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent), restriction-modification system, deoxyribonuclease (adenosine triphosphate-hydrolyzing), adenosine triphosphate-dependent deoxyribonuclease, ATP-dependent DNase, type 1 site-specific deoxyribonuclease) is an enzyme. [1]
66705 Ensembl ENSG00000167968 ENSMUSG00000024136 UniProt Q92874 Q9D1G0 RefSeq (mRNA) NM_001301680 NM_001374 NM_025718 RefSeq (protein) NP_001288609 NP_001365 NP_079994 Location (UCSC) Chr 16: 2.24 – 2.24 Mb Chr 17: 24.66 – 24.66 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Deoxyribonuclease-1-like 2 is an enzyme that in humans is encoded by the DNASE1L2 gene. References ^ a b ...
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In biochemistry, an endodeoxyribonuclease is a class of enzyme which is a type of deoxyribonuclease (a DNA cleaver), itself a type of endonuclease (a nucleotide cleaver). They catalyze cleavage of the phosphodiester bonds in DNA. They are classified with EC numbers 3.1.21 through 3.1.25. Examples include: DNA restriction enzymes
1776 13421 Ensembl ENSG00000163687 ENSMUSG00000025279 UniProt Q13609 O55070 RefSeq (mRNA) NM_004944 NM_001256560 NM_007870 RefSeq (protein) NP_001243489 NP_004935 NP_031896 Location (UCSC) Chr 3: 58.19 – 58.21 Mb Chr 14: 14.48 – 14.51 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Deoxyribonuclease gamma (also termed DNase γ, deoxyribonuclease 1L3, DNASE1L3, of ...
The enzyme complex is composed of three different subunits called RecB, RecC, and RecD and hence the complex is named RecBCD (Figure 1). Before the discovery of the recD gene, [4] the enzyme was known as “RecBC.”