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Drug-induced pigmentation of the skin may occur as a consequence of drug administration, and the mechanism may be postinflammatory hyperpigmentation in some cases, but frequently is related to actual deposition of the offending drug in the skin. [2]: 125–6 The incidence of this change varies, and depends on the type of medication involved.
Postinflammatory hyperpigmentation (PIH) is a skin condition characterized by the darkening of the skin (hyperpigmentation) following an inflammatory injury, such as acne, dermatitis, infectious disease, or trauma. Less frequently, it may occur as a complication of a medical procedure performed on the skin. It is a common cause of skin ...
Contact with skin is dangerous and adequate ventilation should be provided when melting this metal. [2] Many thallium compounds are highly soluble in water and are readily absorbed through the skin. [3] Exposure to them should not exceed 0.1 mg per m 2 of skin in an 8 hour time-weighted average (40-hour working week).
Mercury poisoning is a type of metal poisoning due to exposure to mercury. [3] Symptoms depend upon the type, dose, method, and duration of exposure. [3] [4] They may include muscle weakness, poor coordination, numbness in the hands and feet, skin rashes, anxiety, memory problems, trouble speaking, trouble hearing, or trouble seeing. [1]
The use of unleaded paints and gas has successfully decreased the number of cases of lead heavy metal poisoning. Nickel, chromium, and cadmium: via metal-DNA interactions, these metals can be carcinogenic. [3] Nickel: allergies to nickel, particularly from skin to metal contact via jewelry, are common.
Many metals, particularly heavy metals are toxic, but some are essential, and some, such as bismuth, have a low toxicity. Metals in an oxidation state abnormal to the body may also become toxic: chromium(III) is an essential trace element, but chromium(VI) is a carcinogen. Only soluble metal-containing compounds are toxic.
Melanin is a class of pigment responsible for producing color in the body in places such as the eyes, skin, and hair. The process of melanin synthesis (melanogenesis) starts with the oxidation of l -tyrosine to l-dopa by the enzyme tyrosine hydroxylase , then to l -dopaquinone and dopachrome , which forms melanin.
A toxic heavy metal is a common but misleading term for a metal-like element noted for its potential toxicity. [4] Not all heavy metals are toxic and some toxic metals are not heavy. [ 5 ] Elements often discussed as toxic include cadmium , mercury and lead , [ 6 ] all of which appear in the World Health Organization 's list of 10 chemicals of ...