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Daptomycin, sold under the brand name Cubicin among others, is a lipopeptide antibiotic used in the treatment of systemic and life-threatening infections caused by Gram-positive organisms. [ 4 ] Daptomycin was removed from the World Health Organization's List of Essential Medicines in 2019.
Daptomycin: Cubicin: Gram-positive organisms, but is inhibited by pulmonary surfactant so less effective against pneumonias: Binds to the membrane and cause rapid depolarization, resulting in a loss of membrane potential leading to inhibition of protein, DNA and RNA synthesis. Macrolides(Bs) Azithromycin: Zithromax, Sumamed, Xithrone
Pulmonary toxicity is the medical name for side effects on the lungs. Although most cases of pulmonary toxicity in medicine are due to side effects of medicinal drugs, many cases can be due to side effects of radiation (radiotherapy). Other (non-medical) causes of pulmonary toxicity can be chemical compounds and airborne particulate matter.
Any references on the internet to pneumonoultramicroscopicsilicovolcanoconiosis or silicosis being caused by 'sharp particles [which] lacerate lining of lungs; causing victim to leak air from their lungs while simultaneously bleeding into their lung cavity' [13] are inaccurate. Particles of a size able to enter the lung (< 10 μm ...
Glycopeptide antibiotics are a class of drugs of microbial origin that are composed of glycosylated cyclic or polycyclic nonribosomal peptides.Significant glycopeptide antibiotics include the anti-infective antibiotics vancomycin, teicoplanin, telavancin, ramoplanin, avoparcin and decaplanin, corbomycin, complestatin and the antitumor antibiotic bleomycin.
In the early 20th century, the German chemist Paul Ehrlich was developing theories of selective toxicity based largely on the ability of certain dyes to kill microbes. Gerhard Domagk , who would later win a Nobel Prize for his efforts, made a major breakthrough in 1932 with the discovery of the antibacterial prontosil red (sulfonamidochrysoidine).
Vitamin D toxicity is typically caused by taking high doses of the vitamin in supplement form, not from food or sunlight, Zumpano adds. If you experience side effects, stop taking vitamin D and ...
Following a 40-year break in discovering classes of antibacterial compounds, four new classes of antibiotics were introduced to clinical use in the late 2000s and early 2010s: cyclic lipopeptides (such as daptomycin), glycylcyclines (such as tigecycline), oxazolidinones (such as linezolid), and lipiarmycins (such as fidaxomicin). [77] [78]