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Brunner syndrome is a rare genetic disorder associated with a mutation in the MAOA gene. It is characterized by lower than average IQ (typically about 85), problematic impulsive behavior (such as pyromania, hypersexuality and violence), sleep disorders and mood swings. [1] [2] It was identified in fourteen males from one family in 1993.
A dysfunctional MAOA gene has been correlated with increased aggression levels in mice, [60] [61] and has been correlated with heightened levels of aggression in humans. [62] In mice, a dysfunctional MAOA gene is created through insertional mutagenesis (called 'Tg8'). [60] Tg8 is a transgenic mouse strain that lacks functional MAO-A enzymatic ...
The human genetics related to aggression have been studied and the main genes have been identified. The DAT1 and DRD2 genes are heavily related to the genetics of aggression. [17] [18] The DAT1 gene plays a role for its heavy relation to regulation of neurotransmission. The DRD2 Gene results in humans finding seemingly rewarding paths such as ...
For example, when individuals suffer from a mutation that causes them to have low levels of serotonin, there is an observed increase in impulsivity and depression [8] With neurotransmitters playing a central role in the development of aggressive behaviour, it follows that many of the gene mutations that have been implicated with aggressive ...
A variant of the gene that encodes the neurotransmitter metabolizing enzyme monoamine oxidase-A (MAOA), which relates to neural systems involved in aggression, plays a key role in regulating behavior following threatening events. Brain imaging studies show patterns of arousal in areas of the brain that are associated with aggression in response ...
Stephen Anthony Mobley (July 13, 1965 – March 1, 2005) was a convicted murderer executed by the State of Georgia for the 1991 killing of John C. Collins, a 25-year-old college student working nights as a Domino's pizza store manager. [1]
Psychiatric genetics is a subfield of behavioral neurogenetics and behavioral genetics which studies the role of genetics in the development of mental disorders (such as alcoholism, schizophrenia, bipolar disorder, and autism).
Rare mutations in the gene are associated with Brunner syndrome. [medical citation needed] A study based on the Dunedin cohort concluded that maltreated children with a low-activity polymorphism in the promoter region of the MAO-A gene were more likely to develop antisocial conduct disorders than maltreated children with the high-activity ...