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Low levels of norepinephrine have been closely linked to depression symptoms like difficulty concentrating, lethargy and issues related to your sleep-wake cycle. ... Tricyclic antidepressants are ...
Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants. TCAs were discovered in the early 1950s and were marketed later in the decade. [ 1 ] They are named after their chemical structure , which contains three rings of atoms .
Typical antidepressants include the SSRIs, SNRIs, TCAs, and MAOIs, which act mainly by increasing the levels of the monoamine neurotransmitters serotonin and/or norepinephrine. [1] [2] [3] Among TCAs, trimipramine is an atypical agent in that it appears not to do this. [3]
Imipramine appears to work by increasing levels of serotonin and norepinephrine and by blocking certain serotonin, adrenergic, histamine, and cholinergic receptors. Imipramine was discovered in 1951 and was introduced for medical use in 1957. It was the first TCA to be marketed.
And whereas serotonin norepinephrine reuptake inhibitors (SNRIs, like duloxetine) impact both serotonin and norepinephrine levels, SSRIs focus specifically on serotonin. ... SNRIs and tricyclic ...
Tricyclic antidepressants (TCAs) ... they also increase the level of norepinephrine — a neurotransmitter responsible for regulating alertness, attention, memory and other mental and physical ...
Desipramine, sold under the brand name Norpramin among others, is a tricyclic antidepressant (TCA) used in the treatment of depression. [8] It acts as a relatively selective norepinephrine reuptake inhibitor, though it does also have other activities such as weak serotonin reuptake inhibitory, α 1-blocking, antihistamine, and anticholinergic effects.
Many antidepressants reduce depression by increasing norepinephrine and/or serotonin levels. ... If you currently use an older antidepressant, such as a tricyclic antidepressant (TCA), ...