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[17] Bibliotherapy for adults is a form of self-administered treatment in which structured materials provide a means to alleviate distress. [12] The concept of the treatment is based on the human inclination to identify with others through their expressions in literature and art .
Paradigm's IND application to commence its phase 3 pivotal clinical trial investigating Pentosan Polysulphate Sodium (PPS) for the treatment of pain associated with knee osteoarthritis has been cleared by the US FDA. Approximately 65 sites have been identified throughout the US and Australia. Contracting with many of those sites has been completed.
Knee pain relief of 50% or more following genicular RFA may last from several months to two years, [128] [131] and can be repeated by the same outpatient procedure when pain recurs. [128] Injection of phenol may be used as a neurolytic treatment of sensory knee nerves to relieve chronic pain from knee osteoarthritis. [133] [134]
It is not always certain why arthritis of the knee develops. [citation needed] The knee may become affected by almost any form of arthritis, including those related to mechanical damage of the structures of the knee (osteoarthritis, and post-traumatic arthritis), various autoimmune forms of arthritis (including; rheumatoid arthritis, juvenile arthritis, and SLE-related arthritis, psoriatic ...
Post-traumatic osteoarthritis is the most common variation of post-traumatic arthritis. [3] Between 20 and 50% [4] of all osteoarthritis cases are preceded by post-traumatic arthritis. Patients having post-traumatic osteoarthritis are usually younger than osteoarthritis patients without any previous physical injuries. [5]
In osteoarthritis, joint injection of glucocorticoids (such as hydrocortisone) leads to short term pain relief that may last between a few weeks and a few months. [5] Injections of hyaluronic acid have not produced improvement compared to placebo for knee arthritis, [6] [7] but did increase risk of further pain. [6]