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The Meyer-Overton correlation for anaesthetics. A nonspecific mechanism of general anaesthetic action was first proposed by Emil Harless and Ernst von Bibra in 1847. [9] They suggested that general anaesthetics may act by dissolving in the fatty fraction of brain cells and removing fatty constituents from them, thus changing activity of brain cells and inducing anaesthesia.
General anaesthetics (or anesthetics) are often defined as compounds that induce a loss of consciousness in humans or loss of righting reflex in animals. Clinical definitions are also extended to include an induced coma that causes lack of awareness to painful stimuli, sufficient to facilitate surgical applications in clinical and veterinary practice.
General anaesthesia (UK) or general anesthesia (US) is medically induced loss of consciousness that renders a patient unarousable even by painful stimuli. [5] It is achieved through medications, which can be injected or inhaled, often with an analgesic and neuromuscular blocking agent .
In light of the preclinical and clinical literature, in 2016, the U.S. Food and Drug Administration issued a communication [9] containing a warning that "repeated or lengthy use of general anesthetic and sedation drugs during surgeries or procedures in children younger than three years or in pregnant women during their third trimester may ...
Subsequently, the term and variant spellings like anæsthesia are used in medical literature signifying "insensibility". [28] In 1846, in a letter, Oliver Wendell Holmes proposed the term anesthesia to be used for the state induced by an agent and anesthetic for the agent itself. Holmes motivates this with earlier uses of anesthesia in medical ...
The theories I know are currently know, are only able to explain some of the findings, while others remained unexplained or are in contradiction to the theory. So I would not rule out the lipid-based theories (apart from the very simple ones). Ralf Schmelter 21:45, 2004 Nov 16 (MET)
Self-insertion is a literary device in which the author writes themselves into the story under the guise of, or from the perspective of, a fictional character. [1] The character, overtly or otherwise, behaves like, has the personality of, and may even be described as physically resembling the author of the work.
An applicable example from Stedman's medical dictionary [ edit ] When a constant concentration of an anesthetic such as halothane is inspired, the increase in alveolar concentration is accelerated by concomitant administration of nitrous oxide, because alveolar uptake of the latter creates a potential subatmospheric intrapulmonary pressure that ...