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Progressive multifocal leukoencephalopathy (PML) is a rare and often fatal viral disease characterized by progressive damage (-pathy) or inflammation of the white matter (leuko-) of the brain (-encephalo-) at multiple locations (multifocal). It is caused by the JC virus, which is normally present and kept under control by the immune system. The ...
Promyelocytic leukemia protein (PML) (also known as MYL, RNF71, PP8675 or TRIM19 [5]) is the protein product of the PML gene. PML protein is a tumor suppressor protein required for the assembly of a number of nuclear structures, called PML-nuclear bodies, which form amongst the chromatin [5] of the cell nucleus.
Acute promyelocytic leukemia is characterized by a chromosomal translocation involving the retinoic acid receptor alpha (RARA) gene on chromosome 17. [3] In 95% of cases of APL, the RARA gene on chromosome 17 is involved in a reciprocal translocation with the promyelocytic leukemia gene (PML) on chromosome 15, a translocation denoted as t(15;17)(q22;q21). [3]
A CT of leukoencephalopathy. Leukoencephalopathy (leukodystrophy-like diseases) is a term that describes all of the brain white matter diseases, whether their molecular cause is known or unknown. [1]
Cleveland Clinic is an American nonprofit academic medical center based in Cleveland, Ohio. [2] Owned and operated by the Cleveland Clinic Foundation, an Ohio nonprofit corporation, Cleveland Clinic was founded in 1921 by a group of faculty and alumni from the Case Western Reserve University School of Medicine.
The ceremonial groundbreaking of the Lou Ruvo Center for Brain Health occurred on February 9, 2007. Dignitaries who attended the groundbreaking ceremonies for the $70 million project included founder Larry Ruvo, Frank Gehry, U.S. Senator Harry Reid and John Ensign; U.S. Representative Shelley Berkley, Jon Porter and Dean Heller, Gov. Jim Gibbons, Mayor Oscar Goodman, former Gov. Kenny Guinn ...
Cleveland Clinic Children's (CCC) is a pediatric acute care children's teaching hospital located in Cleveland, Ohio on the main campus of Cleveland Clinic. The hospital has 389 pediatric beds [1] and is affiliated with Cleveland Clinic Lerner College of Medicine, the Case Western Reserve University School of Medicine, Heritage College of Osteopathic Medicine and Kent State University College ...
First released as the Cleveland Clinic Bulletin in 1931, the publication was renamed the Cleveland Clinic Quarterly in 1932 and later rebranded as the CCJM in 1987. [ 1 ] CCJM is a peer-reviewed medical publication distributed monthly to over 123,000 healthcare professionals, including internists, hospitalists, cardiologists , endocrinologists ...
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