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Brunner syndrome is a rare genetic disorder associated with a mutation in the MAOA gene. It is characterized by lower than average IQ (typically about 85), problematic impulsive behavior (such as pyromania, hypersexuality and violence), sleep disorders and mood swings. [1] [2] It was identified in fourteen males from one family in 1993.
The effects of MAOA genes on aggression have also been criticized for being heavily overstated. [49] Indeed, the MAOA gene, even in conjunction with childhood adversity, is known to have a very small effect. [50] The vast majority of people with the associated alleles have not committed any violent acts. [51] [52]
The human genetics related to aggression have been studied and the main genes have been identified. The DAT1 and DRD2 genes are heavily related to the genetics of aggression. [17] [18] The DAT1 gene plays a role for its heavy relation to regulation of neurotransmission. The DRD2 Gene results in humans finding seemingly rewarding paths such as ...
Rare mutations in the gene are associated with Brunner syndrome. [medical citation needed] A study based on the Dunedin cohort concluded that maltreated children with a low-activity polymorphism in the promoter region of the MAO-A gene were more likely to develop antisocial conduct disorders than maltreated children with the high-activity ...
A variant of the gene that encodes the neurotransmitter metabolizing enzyme monoamine oxidase-A (MAOA), which relates to neural systems involved in aggression, plays a key role in regulating behavior following threatening events. Brain imaging studies show patterns of arousal in areas of the brain that are associated with aggression in response ...
[2] [5] He has also researched the link between parenting behavior and child intelligence, [6] as well as the potential for genetic factors to contribute to academic achievement in children. [7] His research has also found a link between a rare form of the MAOA gene (known as the "warrior gene") and violent behavior and weapon use among boys. [8]
Psychiatric genetics is a subfield of behavioral neurogenetics and behavioral genetics which studies the role of genetics in the development of mental disorders (such as alcoholism, schizophrenia, bipolar disorder, and autism).
A 26-year study in New Zealand found strong correlation between experience of childhood abuse and criminal or violent behavior in males with the MAOA gene. [9] In that study, impulsive aggression was found to be nine times more likely to manifest in males with the gene who were abused than in abused males without the gene or males with the gene ...