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The endomysium, meaning within the muscle, is a wispy layer of areolar connective tissue that ensheaths each individual muscle fiber, or muscle cell. [1] [2] [3] It also contains capillaries and nerves. It overlies the muscle fiber's cell membrane: the sarcolemma. Endomysium is the deepest and smallest component of muscle connective tissue.
Unlike the endomysium, the perimysium has large variations in quantity and organization from one muscle group to another. [12] Muscles contain far more perimysial than endomysial connective tissue, and it has also been observed that the ratio of the dry mass of perimysium to that of endomysium ranges between 2.8-1 and 64–1. [13]
The endomysium is a layer of connective tissue that ensheaths a muscle fiber. The endomysium contains a form of transglutaminase called "tissue transglutaminase" or "tTG" for short, and antibodies that bind to this form of transglutaminase are called endomysial autoantibodies (EmA). [6]
Epimysium (plural epimysia [1]) (Greek epi-for on, upon, or above + Greek mys for muscle) is the fibrous tissue envelope that surrounds muscle. [2] It is a layer of dense irregular connective tissue which ensheaths the entire muscle and protects muscles from friction against other muscles and bones. [3]
Deep fascia (or investing fascia) is a fascia, a layer of dense connective tissue that can surround individual muscles and groups of muscles to separate into fascial compartments. This fibrous connective tissue interpenetrates and surrounds the muscles, bones, nerves, and blood vessels of the body.
Muscle cells are grouped into muscle fascicles by enveloping perimysium connective tissue. [1] Fascicles are bundled together by epimysium connective tissue. [1] Muscle fascicles typically only contain one type of muscle cell (either type I fibres or type II fibres), but can contain a mixture of both types.
Myosatellite cells, also known as satellite cells, muscle stem cells or MuSCs, are small multipotent cells with very little cytoplasm found in mature muscle. [1] Satellite cells are precursors to skeletal muscle cells, able to give rise to satellite cells or differentiated skeletal muscle cells. [2]
The perineurium is composed of connective tissue, which has a distinctly lamellar arrangement consisting of one to several concentric layers. The perineurium is composed of perineurial cells, which are epithelioid myofibroblasts.