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Exemestane is an irreversible, steroidal aromatase inactivator of type I, structurally related to the natural substrate 4-androstenedione. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as " suicide ...
Exemestane went through clinical trials in the 1990s and received FDA approval in 1999, marketed as Aromasin. Indication for exemestane is advanced breast cancer in postmenopausal women, where the cancer has progressed following tamoxifen therapy. Exemestane is the first oral aromatase inactivator. [5]
Stereoisomers of Soman, a G-series nerve agent and suicide inhibitor of acetylcholinesterase.Note the non-carbon chiral center.. In biochemistry, suicide inhibition, also known as suicide inactivation or mechanism-based inhibition, is an irreversible form of enzyme inhibition that occurs when an enzyme binds a substrate analog and forms an irreversible complex with it through a covalent bond ...
One of the sweetest ways cats show affection (and dogs, too!), getting licked is a sign that your fur friend considers you to be one of their tribe. Unless licking is excessive (in which case it ...
Many of them, like astragalus and cat's claw, are used to strengthen the dog's immune system so that the pet is more likely to recognize the cancer cells. Unfortunately, herbal remedies are poorly ...
prednisolone – glucocorticoid (steroid) used in the management of inflammation and auto-immune disease, primarily in cats; prednisone – glucocorticoid (steroid) used in the management of inflammation and auto immune disease; pregabalin – neuropathic pain reliever and anti-convulsant; propofol – short acting intravenous drug used to ...