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At steady state, the systemic exposure for armodafinil is 1.8 times the exposure observed after a single dose. The concentration-time profiles of the (R)-(−)-enantiomer following a single dose of 50 mg Nuvigil or 100 mg Provigil (modafinil being a 1:1 mixture of (R)-(−)- and (S)-(−)- enantiomers
Modafinil is generally well-tolerated but can have potential risks and side effects. Common adverse effects of modafinil, experienced by less than 10% of users, include headaches, nausea, and reduced appetite. [93] [94] [20] Anxiety, insomnia, dizziness, diarrhea, and rhinitis are also reported in 5% to 10% of users. [20]
The pharmaceutical company Cephalon, the original United States market rights holder of modafinil, has demonstrated initiative in the development of a successor to the prototypical eugeroic. [25]
Side effects include irregular heartbeat, fatigue, high blood pressure, dry mouth, and eyes that are itchy, red, and/or swollen. Carbonic anhydrase inhibitors (Trusopt, Azopt): This is another ...
Provigil is a combination of R and S isomers of modafinil. Nuvigil uses only the R isomer, with the hope that it will have longer lasting effects in the body. However, Cephalon states that it has no comparative test data on Nuvigil and Provigil, either on efficacy or patient tolerance. Both substances carry a risk of dependency and producing mania.
The clinic also spent nearly $100,000 during that period on Provigil, a stimulant that is “55 times more expensive than the generic equivalent,” the report said.