Search results
Results From The WOW.Com Content Network
In cell biology, adherens junctions (or zonula adherens, intermediate junction, or "belt desmosome" [1]) are protein complexes that occur at cell–cell junctions and cell–matrix junctions in epithelial and endothelial tissues, [2] usually more basal than tight junctions. An adherens junction is defined as a cell junction whose cytoplasmic ...
Spot-like adherens junctions called focal adhesions help cells adhere to extracellular matrix. The cytoskeletal actin filaments that tie into adherens junctions are contractile proteins and in addition to providing an anchoring function, adherens junctions are thought to participate in folding and bending of epithelial cell sheets.
Cell–cell adhesion complexes are essential for the formation of complex animal tissues. β-catenin is part of a protein complex that form adherens junctions. [35] These cell–cell adhesion complexes are necessary for the creation and maintenance of epithelial cell layers and barriers. As a component of the complex, β-catenin can regulate ...
The first identified function of PLEKHA7 was is to contribute to integrity and stability of the zonula adherens junctions by linking the E-cadherin/p120 complex to the minus ends of microtubules (MTs) through Nezha (CAMSAP3). [5] The PLEKHA7-Nezha- MTs complex allows transport of the KIFC3 (a minus end directed motor) to the AJ.
Adjacent epithelial cells are connected by adherens junctions on their lateral membranes. They are located just below tight junctions. Their function is to give shape and tension to cells and tissues and they are also the site of cell-cell signaling. Adherens junctions are made of cell adhesion molecules from the cadherin family. There are over ...
Cadherins (named for "calcium-dependent adhesion") are cell adhesion molecules important in forming adherens junctions that let cells adhere to each other. [1] Cadherins are a class of type-1 transmembrane proteins, and they depend on calcium (Ca 2+) ions to function, hence their name.
A desmosome (/ ˈ d ɛ z m ə ˌ s oʊ m /; [1] [2] "binding body"), also known as a macula adherens (plural: maculae adherentes) (Latin for adhering spot), is a cell structure specialized for cell-to-cell adhesion. A type of junctional complex, they are localized spot-like adhesions randomly arranged on the lateral sides of plasma membranes.
Cadherin-2 is a transmembrane protein expressed in multiple tissues and functions to mediate cell–cell adhesion. In cardiac muscle , Cadherin-2 is an integral component in adherens junctions residing at intercalated discs , which function to mechanically and electrically couple adjacent cardiomyocytes .