Search results
Results From The WOW.Com Content Network
Mycobacterium tuberculosis (M. tb), also known as Koch's bacillus, is a species of pathogenic bacteria in the family Mycobacteriaceae and the causative agent of tuberculosis. [ 1 ] [ 2 ] First discovered in 1882 by Robert Koch , M. tuberculosis has an unusual, waxy coating on its cell surface primarily due to the presence of mycolic acid .
Cryogenic electron microscopy was used to determine that a complex of two identical subunits made from four proteins forms the structure of the type VII secretion system in Mycobacterium smegmatis. [5] T7SS forms a six-sided complex that allows for nearly 165 membrane attachments. [6] This shows how complex the secretion system is.
When cells of M. tuberculosis become phagocytosed, the bacterium upregulates genes encoding the glyoxylate shunt enzymes. [17] Mycobacterium tuberculosis is one of the most well studied pathogens in connection to the enzyme malate synthase. The structure and kinetics of Mycobacterium tuberculosis malate synthase have been well categorized.
Mycobacterium is a genus of over 190 species in the phylum Actinomycetota, assigned its own family, Mycobacteriaceae.This genus includes pathogens known to cause serious diseases in mammals, including tuberculosis (M. tuberculosis) and leprosy in humans.
Most attention have been traditionally devoted to the mycolic acids of Mycobacterium species, which display great variation in length and modifications. Modifications not seen in M. tuberculosis include: [9] Double bonds (cis and trans), in M. smegmatis (with a branch from UmaA1) and M. alvei; ω-1 methoxy, in M. alvei; trans-epoxy group, in M ...
As of June 2006, 82 TB protein structures have been determined, 15 since January 1, 2006. The database of linked structural and functional information that has been constructed using this information can form a lasting basis for understanding M. tuberculosis pathogenesis and for structure-based drug design. [citation needed]
Mycobacterium tuberculosis uses this ESX-1 secretion system to deliver virulence factors into host macrophage and monocyte white blood cells during infection. In Mycobacterium tuberculosis, the core components of the whole ESX-1 secretion system include Rv3877, and two AAA ATPases, including Rv3870 and Rv3871, a cytosolic protein. The ESAT-6 ...
Cord factor, or trehalose dimycolate (TDM), is a glycolipid molecule found in the cell wall of Mycobacterium tuberculosis and similar species. It is the primary lipid found on the exterior of M. tuberculosis cells. [1] Cord factor influences the arrangement of M. tuberculosis cells into long and slender formations, giving its name. [2]