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Microtubule and tubulin metrics [1]. Microtubules are polymers of tubulin that form part of the cytoskeleton and provide structure and shape to eukaryotic cells. Microtubules can be as long as 50 micrometres, as wide as 23 to 27 nm [2] and have an inner diameter between 11 and 15 nm. [3]
Nowadays there are many scientific investigations of the acetylation done in some microtubules, specially the one by α-tubulin N-acetyltransferase (ATAT1) which is being demonstrated to play an important role in many biological and molecular functions and, therefore, it is also associated with many human diseases, specially neurological diseases.
Tubulin alpha-1A chain is a protein that in humans is encoded by the TUBA1A gene. [5] [6] [7] Tubulin alpha-1A chain is a type of alpha-tubulin involved in the formation of microtubules, which are structural proteins that play a role in the cytoskeletal structure. Microtubules are composed of heterodimers of alpha- and beta-tubulin molecules.
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families.
7278 n/a Ensembl ENSG00000198033 n/a UniProt Q1ZYQ1 P0DPH8 n/a RefSeq (mRNA) NM_079836 NM_006001 n/a RefSeq (protein) NP_525125 NP_005992 n/a Location (UCSC) Chr 13: 19.17 – 19.18 Mb n/a PubMed search n/a Wikidata View/Edit Human Tubulin alpha-3C/D chain is a protein that in humans is encoded by the TUBA3C gene. Function Microtubules of the eukaryotic cytoskeleton perform essential and ...
The primary pathway by which microtubule nucleation is assisted requires the action of a third type of tubulin, γ-tubulin, which is distinct from the α and β subunits that compose the microtubules themselves. The γ-tubulin combines with several other associated proteins to form a conical structure known as the γ-tubulin ring complex (γ-TuRC).
[5] [6] [7] Tubulin is the major constituent of microtubules, a key components of the cytoskeleton. It binds two molecules of GTP , one at an exchangeable site on the beta-chain and one at a non-exchangeable site on the alpha-chain.
The microtubule-organizing center (MTOC) is a structure found in eukaryotic cells from which microtubules emerge. MTOCs have two main functions: the organization of eukaryotic flagella and cilia and the organization of the mitotic and meiotic spindle apparatus, which separate the chromosomes during cell division.