Search results
Results From The WOW.Com Content Network
The sodium–potassium pump a critical enzyme for regulating sodium and potassium levels in cells. Potassium is the main intracellular ion for all types of cells, while having a major role in maintenance of fluid and electrolyte balance. [1] [2] Potassium is necessary for the function of all living cells and is thus present in all plant and ...
K ir export surplus potassium into collecting tubules for removal in the urine, or alternatively may be involved in the reuptake of potassium back into the body. neurons and in heart cells: G-protein activated IRKs (K ir 3) are important regulators, modulated by neurotransmitters. A mutation in the GIRK2 channel leads to the weaver mouse mutation.
Top view of a potassium channel with potassium ions (purple) moving through the pore (in the center). ( PDB : 1BL8 ) Potassium channels have a tetrameric structure in which four identical protein subunits associate to form a fourfold symmetric ( C 4 ) complex arranged around a central ion conducting pore (i.e., a homotetramer).
[K +] o = extracellular concentration of potassium, measured in mol·m −3 or mmol·l −1 [K +] i = intracellular concentration of potassium; Even if two different ions have the same charge (i.e., K + and Na +), they can still have very different equilibrium potentials, provided their outside and/or inside concentrations differ. Take, for ...
The major intracellular compartments are endoplasmic reticulum, Golgi apparatus, and mitochondria. On the basis of localization, ion channels are classified as: Plasma membrane channels Examples: Voltage-gated potassium channels (Kv), Sodium channels (Nav), Calcium channels (Cav) and Chloride channels (ClC)
An ATP-sensitive potassium channel (or K ATP channel) is a type of potassium channel that is gated by intracellular nucleotides, ATP and ADP. ATP-sensitive potassium channels are composed of K ir 6.x-type subunits and sulfonylurea receptor (SUR) subunits, along with additional components. [ 1 ]
Calcium-activated potassium channel subunit alpha-1 also known as large conductance calcium-activated potassium channel, subfamily M, alpha member 1 (K Ca 1.1), or BK channel alpha subunit, [5] is a voltage gated potassium channel encoded by the KCNMA1 gene and characterized by their large conductance of potassium ions (K+) through cell membranes.
The intracellular side of the membrane contains both amino and carboxy termini. [7] The high resolution crystallographic structure of the rat K v α1.2/β2 channel has recently been solved (Protein Databank Accession Number 2A79 ), [ 8 ] and then refined in a lipid membrane-like environment ( PDB : 2r9r ).