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Carbidopa/levodopa, also known as levocarb and co-careldopa, is the combination of the two medications carbidopa and levodopa. [6] It is primarily used to manage the symptoms of Parkinson's disease, but it does not slow down the disease or stop it from getting worse. [6]
Existing preparations are carbidopa/levodopa (co-careldopa, trade names Sinemet, Pharmacopa, Atamet) and benserazide/levodopa (co-beneldopa, trade name Madopar). Levodopa has also been related to a dopamine dysregulation syndrome, which is a compulsive overuse of the medication, and punding. [5]
Here are seven supplement combinations you should not take together or should be careful about combining. Related: 7 Things You Should Look for When Buying a Supplement, According to Dietitians 1.
Trade names include Sinemet, Pharmacopa, Atamet, and Stalevo. As a drug, it is used in the clinical treatment of Parkinson's disease and dopamine-responsive dystonia. l-DOPA has a counterpart with opposite chirality, d-DOPA. As is true for many molecules, the human body produces only one of these isomers (the l-DOPA form).
The name "Sinemet" is (most likely) a combination of two Latin words: "sine" which means "without", and "emet" which means "vomiting". Sinemet is a combination of levodopa, which reduces the symptoms of Parkinson's but causes severe nausea and vomiting if taken alone, plus carbidopa, which prevents the nausea and vomiting.
Levodopa is taken by mouth, by inhalation, through an intestinal tube, or by administration into fat (as foslevodopa). [3] Side effects of levodopa include nausea, the wearing-off phenomenon, dopamine dysregulation syndrome, and levodopa-induced dyskinesia, among others. [3]
As Kim Yawitz, R.D., puts it, most people take vitamins and supplements because they want to be healthier, but taking the wrong ones together can do more harm than good.
Characteristic symptoms are increased muscle tone (dystonia, such as clubfoot) and Parkinsonian features, typically absent in the morning or after rest but worsening during the day and with exertion. Children with dopamine-responsive dystonia are often misdiagnosed as having cerebral palsy .