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Melatonin has emerged in recent years as one of the most popular sleep supplements, given its reputation for being effective as well as safe. Nearly two-thirds of adults say they’ve turned to ...
[9] [12] As a hormone, melatonin is released by the pineal gland and is involved in sleep–wake cycles. [9] [12] As a supplement, it is often used for the attempted short-term treatment of disrupted sleep patterns, such as from jet lag or shift work, and is typically taken orally.
Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.
Sleep deprivation, also known as sleep insufficiency [2] or sleeplessness, is the condition of not having adequate duration and/or quality of sleep to support decent alertness, performance, and health. It can be either chronic or acute and may vary widely in severity.
The sleep disturbance causes clinically significant distress or impairment in social, occupational, educational, academic, behavioral, or other important areas of functioning. The sleep difficulty occurs at least three nights per week. The sleep difficulty is present for at least three months.
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