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The most common side effect is a burning sensation at the application site. Other reactions, such as itching, eczema or skin dryness, are rare. [3] Bifonazole is a potent aromatase inhibitor in vitro. [4] [5]
Stasis dermatitis is diagnosed clinically by assessing the appearance of red plaques on the lower legs and the inner side of the ankle. Stasis dermatitis can resemble a number of other conditions, such as cellulitis and contact dermatitis, and at times needs the use of a duplex ultrasound to confirm the diagnosis or if clinical diagnosis alone is not sufficient.
Immunosuppressants can cause significant side effects and some require regular blood tests. The most commonly used are ciclosporin, azathioprine, and methotrexate. Dupilumab is a new [note 1] medication that improves eczema lesions, especially moderate to severe eczema. [74]
Ichthammol or ammonium bituminosulfonate (brand name Ichthyol), also known as black ointment, is a medication derived from sulfur-rich oil shale (bituminous schists). It is used (sometimes in combination with zinc oxide) as a treatment for different skin diseases, including eczema and psoriasis (see below).
Side effects may include irritation of the skin and discoloration of clothing. [2] A harsh burn on a child from an undissolved tablet has been reported. [10] For treating eczema, it is recommended using for a few days at a time due to the possibility of it irritating the skin. [10] Higher concentration solutions can result in chemical burns. [11]
Hypochlorous acid is well-tolerated by most people, and serious side effects are rare. With that being said, mild irritation—particularly if used excessively—is not unheard of.
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