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Adenovirus infection is a contagious viral disease, caused by adenoviruses, commonly resulting in a respiratory tract infection. [1] [9] Typical symptoms range from those of a common cold, such as nasal congestion, rhinitis, and cough, to difficulty breathing as in pneumonia. [9]
Human adenovirus 36 (HAdV-36) or Ad-36 or Adv36 is one of 52 types of adenoviruses known to infect humans. AD-36, first isolated in 1978 from the feces of a girl suffering from diabetes and enteritis, [ 1 ] has long been recognized as a cause of respiratory and eye infections in humans. [ 2 ]
Adenovirus varieties have been explored extensively as a viral vector for gene therapy and also as an oncolytic virus. [1]Of the many different viruses being explored for oncolytic potential, an adenovirus was the first to be approved by a regulatory agency, the genetically modified H101 strain.
The 2018 United States adenovirus outbreak was an occurrence in which an unusual number of adenovirus cases were reported at two locations, one in Maryland and one in New Jersey, from September to December 2018, resulting in deaths in both states. [1] [2] At least 35 people contracted the disease in each location of the outbreak.
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In August 2022, 9 children in a U.S. case series of hepatitis of unknown cause [7] and 27 of 30 children in a U.K. case series with hepatitis of unknown cause who underwent molecular testing [8] tested positive for human adenovirus type 41 in a sample. It was unclear whether human adenovirus 41 was the cause, however. [citation needed]
Adenovirus serotype 14 (Ad14) is a serovar of adenovirus which, unlike other adenovirus serovars, is known to cause potentially fatal adenovirus infections.According to the United States Centers for Disease Control and Prevention (CDC), as of September 2007, outbreaks have been identified in four states in the U.S., with ten identified deaths since May 2006.
An adenovirus vaccine is a vaccine against adenovirus infection. [3] According to the American CDC, "There is currently no adenovirus vaccine available to the general public. [4] It should not be confused with the strategy of using adenovirus as a viral vector to develop vaccines for other pathogens, or as a general gene carrier. [5] [6] [7]