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Amlodipine's safety in pregnancy has not been established, although reproductive toxicity at high doses is known. Whether amlodipine enters the milk of breastfeeding mothers is also unknown. [7] [6] Those who have heart failure, or recently had a heart attack, should take amlodipine with caution. [29]
The negative chronotropic effects of CCBs make them a commonly used class of agents in individuals with atrial fibrillation or flutter in whom control of the heart rate is generally a goal. Negative chronotropy can be beneficial when treating a variety of disease processes because lower heart rates represent lower cardiac oxygen requirements.
This is in contrast to other commonly used rate-reducing medications, such as beta-blockers and calcium channel blockers, which not only reduce heart rate, but also the cardiac contractility. Given the selective decrease in rate without loss of contractility, ivabradine may prove efficacious for treatment of congestive heart failure with ...
When it comes to resting heart rate, lower is better, says Dr. Steinbaum. “It usually means your heart muscle is in better condition and doesn’t have to work as hard to maintain a steady beat ...
However, oftentimes lower heart rates can be totally normal, and a well-trained athlete can have a normal heart rate in the 50s or as low as 40 without any cause for concern, he notes.
They decrease conduction through the AV node, and shorten phase two (the plateau) of the cardiac action potential. They thus reduce the contractility of the heart, so may be inappropriate in heart failure. However, in contrast to beta blockers, they allow the body to retain adrenergic control of heart rate and contractility. [citation needed]
Cardiovascular agents are drugs that affect the rate and intensity of cardiac contraction, blood vessel diameters, blood volume, blood clotting and blood cholesterol levels. [1] They are indicated to treat diseases related to the heart or the vascular system (blood vessels), such as hypertension , hyperlipidemia , coagulation disorders , heart ...
Those are times to seek out help because it may not be a reflection of your resting heart rate, but an abnormal heart rhythm that should get evaluated.” Having a pulse over 100 bpm is called ...