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TOL-463 is an anti-infective medication which is under development for the treatment of bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC) (vaginal yeast infection). [ 3 ] [ 1 ] [ 4 ] [ 2 ] It is a boric acid -based vaginal anti-infective enhanced with ethylenediaminetetraacetic acid (EDTA) which was designed to have improved activity ...
The compound has also been used to treat recurrent bacterial vaginosis as a maintenance or suppressive therapy. [ 5 ] [ 21 ] [ 10 ] [ 22 ] It is recommended at a dose of 600 mg/day for 2 to 3 weeks for treatment of acute recurrent bacterial vaginosis. [ 5 ]
Bacterial vaginosis (BV) is an infection of the vagina caused by excessive growth of bacteria. [ 6 ] [ 12 ] Common symptoms include increased vaginal discharge that often smells like fish. [ 2 ] The discharge is usually white or gray in color. [ 2 ]
Patients should be advised to avoid sexual intercourse for at least 1 week and until they and their partner(s) have completed treatment and follow-up." [32] Bacterial vaginosis: The most commonly used antibiotics are metronidazole, available in both pill and gel form, and clindamycin available in both pill and cream form. [11]
It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vaginosis. [10] It is effective for dracunculiasis, giardiasis, trichomoniasis, and amebiasis. [10] It is an option for a first episode of mild-to-moderate Clostridioides difficile colitis if vancomycin or fidaxomicin is unavailable.
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