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Prostacyclin is produced in endothelial cells, which line the walls of arteries and veins, [14] from prostaglandin H 2 (PGH 2) by the action of the enzyme prostacyclin synthase. Although prostacyclin is considered an independent mediator, it is called PGI 2 (prostaglandin I 2 ) in eicosanoid nomenclature, and is a member of the prostanoids ...
Adverse effects [ edit ] Since treprostinil is a vasodilator , its antihypertensive effect may be compounded by other medications that affect the blood pressure, including calcium channel blockers , diuretics , and other vasodilating agents.
Chemical structure of prostaglandin E 1 (alprostadil) Chemical structure of prostaglandin I 2 (prostacyclin). Prostaglandins (PG) are a group of physiologically active lipid compounds called eicosanoids [1] that have diverse hormone-like effects in animals.
Selexipag, sold under the brand name Uptravi, is a medication developed by Actelion for the treatment of pulmonary arterial hypertension (PAH). [3] [4] Selexipag and its active metabolite, ACT-333679 (or MRE-269, the free carboxylic acid), are agonists of the prostacyclin receptor, which leads to vasodilation in the pulmonary circulation. [5]
Iloprost is a synthetic analogue of prostacyclin PGI 2.Iloprost dilates systemic and pulmonary arterial vascular beds. It also affects platelet aggregation but the relevance of this effect to the treatment of pulmonary hypertension is unknown.
A common side effect of prostaglandin E 2 is its effect on gastrointestinal smooth muscle resulting in nausea, vomiting and diarrhea. Other side effects include headache, shivering, and chills. [4] The suppository form of prostaglandin E 2 is associated with increased severity of these symptoms.
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