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The cause of multiple myeloma is unknown. [4] Risk factors include obesity, radiation exposure, family history, age and certain chemicals. [5] [11] [12] There is an increased risk of multiple myeloma in certain occupations. [13] This is due to the occupational exposure to aromatic hydrocarbon solvents having a role in causation of multiple ...
These causes are rare and constitute about 1% of all causes of hypercalcemia of malignancy. [22] Hypercalcemia of malignancy usually portends a poor prognosis, and the medial survival is 25–52 days of its development. [22] It has an incidence of 30% in those with cancer, and the prevalence is estimated to be about 2-3% in the United States. [22]
This means the nerve signals are interrupted and are slower. This causes muscle contractions to be irregular and fewer, resulting in an increased colon transit time. [12] The feces stay in the colon for a longer period of time, meaning that more water is absorbed. This leads to harder stools and therefore increases the symptoms of constipation.
Monoclonal gammopathy, also known as paraproteinemia, is the presence of excessive amounts of myeloma protein or monoclonal gamma globulin in the blood. It is usually due to an underlying immunoproliferative disorder or hematologic neoplasms, especially multiple myeloma. It is sometimes considered equivalent to plasma cell dyscrasia.
In hematology, plasma cell dyscrasias (also termed plasma cell disorders and plasma cell proliferative diseases) are a spectrum of progressively more severe monoclonal gammopathies in which a clone or multiple clones of pre-malignant or malignant plasma cells (sometimes in association with lymphoplasmacytoid cells or B lymphocytes) over-produce and secrete into the blood stream a myeloma ...
Obstructed defecation is one of the causes of chronic constipation. [22] ODS is a loose term, [20] consisting of a constellation of possible symptoms, [7] caused by multiple, complex [23] and poorly understood [24] disorders which may include both functional and organic disorders. [18]
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