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Duration of treatment with atorvastatin is unlikely to increase the risk of muscle-related side effects as most occur within the first year of treatment, after which the risk is not increased further. [64] The known cardiovascular benefits of atorvastatin over time outweigh the low risk of muscle-related side effects. [65] [64]
Muscle pain and other symptoms often cause patients to stop taking a statin. [87] This is known as statin intolerance. A 2021 double-blind multiple crossover randomized controlled trial (RCT) in statin-intolerant patients found that adverse effects, including muscle pain, were similar between atorvastatin and placebo. [88]
Tendinopathy is a type of tendon disorder that results in pain, swelling, and impaired function. [2] The pain is typically worse with movement. [2] It most commonly occurs around the shoulder (rotator cuff tendinitis, biceps tendinitis), elbow (tennis elbow, golfer's elbow), wrist, hip, knee (jumper's knee, popliteus tendinopathy), or ankle (Achilles tendinitis).
Stage 1: Tendon is intact, but damaged. Stage 2: Tendon has ruptured. Foot begins to deform. Stage 3: The foot is significantly deformed. Cartilage begins to degenerate. Stage 4: Ankle joint begins to degenerate. [1] In early stages, patients will describe foot and ankle pain. Swelling will also be present.
The treatments may include joint replacement surgery for severely damaged joints, immunosuppressants for immune system dysfunction, antibiotics when an infection is the cause, and discontinuing medication when an allergic reaction is the cause. When treating the primary cause, pain management may still play a role in treatment.
Prolotherapy involves the injection of an irritant solution into a joint space, [22] weakened ligament, or tendon insertion to relieve pain. [ 7 ] Most commonly, hyperosmolar dextrose (a sugar) is the solution used; [ 23 ] glycerine , [ 20 ] lidocaine (a commonly used local anesthetic ), [ 24 ] phenol , [ 20 ] and sodium morrhuate (a derivative ...
It is accompanied by alterations in the tendon's structure and mechanical properties. [2] The most common symptoms are pain and swelling around the back of the ankle. [1] The pain is typically worse at the start of exercise and decreases thereafter. [3] Stiffness of the ankle may also be present. [2] Onset is generally gradual. [1]
Ezetimibe/atorvastatin (trade names Liptruzet, Atozet) is a cholesterol lowering combination drug. In the United States, it was approved in May 2013, by the Food and Drug Administration for the treatment of elevated low-density lipoprotein (LDL) in patients with primary or mixed hyperlipidemia as adjunctive therapy to diet. [ 1 ]