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In null-hypothesis significance testing, the p-value [note 1] is the probability of obtaining test results at least as extreme as the result actually observed, under the assumption that the null hypothesis is correct. [2] [3] A very small p-value means that such an extreme observed outcome would be very unlikely under the null hypothesis.
A clinical researcher might report: "in my own experience treatment X does not do well for condition Y". [3] [4] The use of a P value cut-off point of 0.05 was introduced by R.A. Fisher; this led to study results being described as either statistically significant or non-significant. [5]
The procedures of Bonferroni and Holm control the FWER under any dependence structure of the p-values (or equivalently the individual test statistics).Essentially, this is achieved by accommodating a `worst-case' dependence structure (which is close to independence for most practical purposes).
The p-value is not the probability that the observed effects were produced by random chance alone. [2] The p-value is computed under the assumption that a certain model, usually the null hypothesis, is true. This means that the p-value is a statement about the relation of the data to that hypothesis. [2]
Internal consistency is the extent to which the items on a scale generally measure the same thing. Cronbach's alpha values (an estimate of internal consistency) median (average) values were 0.84 for the personality pattern scales, 0.83 for the clinical syndrome scales, and 0.80 for the Grossman Facet Scales. [1]
This is because the binomial distribution becomes asymmetric as that probability deviates from 1/2. There are two methods to define the two-tailed p-value. One method is to sum the probability that the total deviation in numbers of events in either direction from the expected value is either more than or less than the expected value.
The weighted harmonic mean of p-values , …, is defined as = = = /, where , …, are weights that must sum to one, i.e. = =.Equal weights may be chosen, in which case = /.. In general, interpreting the HMP directly as a p-value is anti-conservative, meaning that the false positive rate is higher than expected.
Under Fisher's method, two small p-values P 1 and P 2 combine to form a smaller p-value.The darkest boundary defines the region where the meta-analysis p-value is below 0.05.. For example, if both p-values are around 0.10, or if one is around 0.04 and one is around 0.25, the meta-analysis p-value is around 0