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Doxorubicin, sold under the brand name Adriamycin among others, is a chemotherapy medication used to treat cancer. [10] This includes breast cancer , bladder cancer , Kaposi's sarcoma , lymphoma , and acute lymphocytic leukemia . [ 10 ]
Doxorubicin localisation to nuclei. Localisation of doxorubicin (red) in the nuclei of MCF-7 cc10 cells. Green fluorescence represents lysosome. [25] The anthracyclines have been widely studied for their interactions with cellular components and impact on cellular processes. This includes studies in cultured cells and in whole animal systems.
The anthracycline skeleton of doxorubicin (DXR) is produced by a Type II polyketide synthase (PKS) in streptomyces peucetius.First, a 21-carbon decaketide chain (Fig 1. (1)) is synthesized from a single 3-carbon propionyl group from propionyl-CoA, and 9 2-carbon units derived from 9 sequential decarboxylative condensations of malonyl-CoA.
cBR96-doxorubicin immunoconjugate (BMS-182248/SGN-15; also known as cBR96-Dox) is an antibody-drug conjugate or (ADC) directed to the Lewis-Y antigen designed for the treatment of cancer. The payload is the chemotherapy drug doxorubicin which is connected with a hydrazone linker to cysteine residues of the Lewis-Y specific (chimeric) monoclonal ...
Drugs with medium risk include doxorubicin and platinum analogs such as cisplatin and carboplatin. [111] On the other hand, therapies with low risk of gonadotoxicity include plant derivatives such as vincristine and vinblastine, antibiotics such as bleomycin and dactinomycin, and antimetabolites such as methotrexate, mercaptopurine, and 5 ...
Red dye No. 3 shows up in a lot of processed foods, Cording says. “Candy is where it’s most commonly seen,” she says. “But it’s also in certain drinks, like oral nutrition supplements ...
S. peucetius produces the anthracycline antitumor antibiotics daunorubicin and doxorubicin (also known as adriamycin). [3] Recent work has identified an antibacterial macrolide, peucemycin, with activity against growth of S. aureus, P. hauseri, and S. enterica. [4]
Why Do So Many Fast-Food Chains Use Red? Aside from just grabbing our attention, the color red stimulates appetite and hunger. You may not even realize it, but the color red will make you want to eat.