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Plecanatide, sold under the brand name Trulance, is a medication for the treatment of chronic idiopathic constipation (CIC) [4] and irritable bowel syndrome with constipation. [5] It is available in India under the brand name Plectide (OQM Div, MSN Laboratories, India).
More than 10% of people taking linaclotide have diarrhea. Between 1% and 10% of people have decreased appetite, dehydration, low potassium, dizziness when standing up too quickly , nausea, vomiting, urgent need to defecate, fecal incontinence, and bleeding in the colon, rectum, and anus.
The pandemic and responses to it damaged the global economy. On 27 February 2020, worries about the outbreak crushed US stock indexes, which posted their sharpest falls since 2008. [456] Tourism collapsed due to travel restrictions, closing of public places including travel attractions, and advice of governments against travel.
A medical dictionary definition of pandemic is "an epidemic occurring on a scale that crosses international boundaries, usually affecting people on a worldwide scale". [15] A disease or condition is not a pandemic merely because it is widespread or kills many people; it must also be infectious.
The CDC then distributed 160,000 defective tests, leaving the US with no testing capacity in the early weeks of the pandemic. By February 27, fewer than 4,000 tests had been conducted in the U.S. [21] CDC released a corrected test in March 2020. [22] By then the pandemic had spread across the country.
By April 25, the U.S. had more than 905,000 confirmed coronavirus cases and nearly 52,000 deaths, giving it a mortality rate around 5.7 percent. (In comparison, Spain's mortality rate was 10.2 percent and Italy's was 13.5 percent.) [87] [88] In April 2020, more than 10,000 American deaths had occurred in nursing homes.
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