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On average, statins can lower LDL cholesterol by 1.8 mmol/L (70 mg/dL), which translates into an estimated 60% decrease in the number of cardiac events (heart attack, sudden cardiac death) and a 17% reduced risk of stroke after long-term treatment. [36] A greater benefit is observed with high-intensity statin therapy. [37]
A 2014 meta-analysis showed high-dose statin therapy was significantly superior compared to moderate or low-intensity statin therapy in reducing plaque volume in people with acute coronary syndrome. [28] The SATURN trial, which compared the effects of high-dose atorvastatin and rosuvastatin, also confirmed these findings. [29]
Rosuvastatin, sold under the brand name Crestor among others, is a statin medication, used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. [6]
Statin-associated autoimmune myopathy (SAAM), also known as anti-HMGCR myopathy, is a very rare form of muscle damage caused by the immune system in people who take statin medications. [1] However, there are cases of SAAM in patients who have not taken statin medication, and this can be explained by the exposure to natural sources of statin ...
For the past seven years, Variety has honored the top songs of the year and the Hitmakers behind them, with a special issue of the magazine and accompanying online rollout, and a celebration ...
Statins may improve quality of life when used in people without existing cardiovascular disease (i.e. for primary prevention). [74] Statins decrease cholesterol in children with hypercholesterolemia, but no studies as of 2010 show improved outcomes [76] and diet is the mainstay of therapy in childhood. [39]
Type 2 statins Statins that are fully synthetic and have larger groups linked to the HMG-like moiety are often referred to as type 2 statins. One of the main differences between the type 1 and type 2 statins is the replacement of the butyryl group of type 1 statins by the fluorophenyl group of type 2 statins.
Ohio State’s run to the national championship has resulted in a new contract for coach Ryan Day. The school announced Thursday that Day had signed a contract extension through the 2031 season.