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The increase in pulse pressure may result in increased damage to blood vessels in target organs such as the brain or kidneys. [ 23 ] [ 24 ] This effect may be exaggerated if the increase in arterial stiffness results in reduced wave reflection and more propagation of the pulsatile pressure into the microcirculation .
The high blood pressure is gradual at early stages and may take at least 10–15 years to fully develop. Besides diabetes, other factors that may also increase high blood pressure include obesity, insulin resistance and high cholesterol levels. In general, fewer than 25 percent of diabetics have good control of their blood pressure.
A diagram explaining factors affecting arterial pressure. Pathophysiology is a study which explains the function of the body as it relates to diseases and conditions. The pathophysiology of hypertension is an area which attempts to explain mechanistically the causes of hypertension, which is a chronic disease characterized by elevation of blood pressure.
Uncontrollable increase in blood pressure can cause damage to the arteries that are present around kidneys, and thus restrict the blood to deliver. Due to inconsistent fluctuations in blood pressure, this can cause additional problems to people with pre-existing heart or blood vessel conditions such as angina, cerebral aneurysm or aortic ...
Inflammaging is thought to be caused by a loss of control over systemic inflammation resulting in chronic overstimulation of the innate immune system. Inflammaging is a significant risk factor in mortality and morbidity in aged individuals. [2] [3] [4] Inflammation is essential to protect against viral and bacterial infection, as well as ...
In medicine, systolic hypertension is defined as an elevated systolic blood pressure (SBP). [1] If the systolic blood pressure is elevated (>140) with a normal (<90) diastolic blood pressure (DBP), it is called isolated systolic hypertension. [2] Eighty percent of people with systolic hypertension are over the age of 65 years old. [3] Isolated ...
Chronic systemic inflammation (SI) is the result of release of pro-inflammatory cytokines from immune-related cells and the chronic activation of the innate immune system.It can contribute to the development or progression of certain conditions such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease, autoimmune and neurodegenerative ...
The bladder should be emptied before a person's blood pressure is measured since this can increase blood pressure by up to 15/10 mmHg. [91] Multiple blood pressure readings (at least two) spaced 1–2 minutes apart should be obtained to ensure accuracy. [92]