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MGMT (O-6-methylguanine-DNA methyltransferase) is an important cancer biomarker because it is involved in the repair of DNA damage and is often silenced or inactivated in cancer cells. The loss of MGMT function leads to a higher rate of mutations, promoting the formation and progression of tumors.
20203 Ensembl ENSG00000160307 ENSMUSG00000033208 UniProt P04271 P50114 RefSeq (mRNA) NM_006272 NM_009115 RefSeq (protein) NP_006263 NP_033141 Location (UCSC) Chr 21: 46.6 – 46.61 Mb Chr 10: 76.09 – 76.1 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse S100 calcium-binding protein B (S100B) is a protein of the S100 protein family. S100 proteins are localized in the cytoplasm and ...
CD133 is expressed in hematopoietic stem cells, [9] endothelial progenitor cells, [10] glioblastoma, neuronal and glial stem cells, [11] various pediatric brain tumors, [12] as well as adult kidney, mammary glands, trachea, salivary glands, uterus, placenta, digestive tract, testes, and some other cell types.
3417 15926 Ensembl ENSG00000138413 ENSMUSG00000025950 UniProt O75874 O88844 RefSeq (mRNA) NM_005896 NM_001282386 NM_001282387 NM_001111320 NM_010497 RefSeq (protein) NP_001269315 NP_001269316 NP_005887 NP_001104790 NP_034627 Location (UCSC) Chr 2: 208.24 – 208.27 Mb Chr 1: 65.2 – 65.23 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Isocitrate dehydrogenase 1 (NADP+), soluble is ...
Glioblastoma pre (left) and post (right) resection. Surgery is the first stage of treatment of glioblastoma. An average GBM tumor contains 10 11 cells, which is on average reduced to 10 9 cells after surgery (a reduction of 99%). Benefits of surgery include resection for a pathological diagnosis, alleviation of symptoms related to mass effect ...
[11] [12] As a result, DAP3 could serve as a potential biomarker to monitor the effectiveness of therapeutic treatments such as chemotherapy. [11] However, in other cancers, such as glioblastoma multiforme (GBM) and thymoma, DAP3 expression was found to be upregulated. [10] [14] Thus, the specific role of DAP3 in various cancers requires ...
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