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Lamotrigine is considered a first-line agent for the treatment of bipolar depression. It is effective in preventing the recurrence of both mania and depression, but it has not proved useful in treating acute mania. [2] Zonisamide (trade name Zonegran), another anti-convulsant, also may show promise in treating bipolar depression. [18]
Treatment of bipolar disorder using antidepressants may carry a risk of affective ... A first-line treatment for depression in bipolar disorder is a combination of ...
Onset of Bipolar Disorder. Signs of bipolar disorder generally emerge in young adulthood. Research suggests that 70 percent of people with bipolar disorder experience their first manic episode ...
The Network for Mood and Anxiety Treatments recommends olanzapine as a first-line maintenance treatment for bipolar disorder and the combination of olanzapine with fluoxetine as a second-line treatment for bipolar depression. [34] A review on the efficacy of olanzapine as maintenance therapy in people with bipolar disorder was published in 2006 ...
The drug seems ineffective in the treatment of current rapid-cycling, acute mania, or acute depression in bipolar disorder. [25] Lamotrigine has been shown to be as effective as lithium, the standard treatment for bipolar disorder. [26] Lamotrigine has not demonstrated clear efficacy in treating acute mood episodes, either mania or depression.
Lithium is the "classic" mood stabilizer, the first to be approved by the US FDA, and still popular in treatment. Therapeutic drug monitoring is required to ensure lithium levels remain in the therapeutic range: 0.6 to 0.8 or 0.8–1.2 mEq/L (or millimolar). Signs and symptoms of toxicity include nausea, vomiting, diarrhea, and ataxia. [3]
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