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Lisinopril leaves the body completely unchanged in the urine. [1] [16] The half-life of lisinopril is 12 hours, and is increased in people with kidney problems. [1] [16] While the plasma half-life of lisinopril has been estimated between 12 and 13 hours, the elimination half-life is much longer, at around 30 hours. [18]
Cold sensitivity or cold intolerance is unusual discomfort felt by some people when in a cool environment. [ 1 ] Cold sensitivity may be a symptom of hypothyroidism , anemia , low body weight, iron deficiency , vitamin B 12 deficiency , fevers , fibromyalgia or vasoconstriction . [ 2 ]
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How these symptoms affect the patient depends on to which organs or body parts blood supply is inhibited. Typical symptoms of Flammer syndrome are cold hands or feet, low blood pressure, occasional white and red patches on the face or neck, and migraine-like pain or a feeling of pressure behind the upper eyelid.
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Lisinopril/hydrochlorothiazide, sold under the brand name Zestoretic among others, is a fixed-dose combination medication used for the treatment of high blood pressure (hypertension). [2] It contains lisinopril , an ACE inhibitor , and hydrochlorothiazide , a diuretic .
Some common locations of angioedema are the face, particularly the lips and around the eyes, hands and feet, and genitalia. [2] A rare, yet serious complication is one inside the abdomen, the symptom usually being severe stomach upset, which is much less obvious than the other locations.