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Bortezomib, sold under the brand name Velcade among others, is an anti-cancer medication used to treat multiple myeloma and mantle cell lymphoma. [4] This includes multiple myeloma in those who have and have not previously received treatment. [ 3 ]
Bortezomib/dexamethasone is a combination drug against multiple myeloma. [1] When bortezomib is used by the trade name Velcade, the combination is called Vel/Dex (or Vel-Dex or Veldex ). Bortezomib is a proteasome inhibitor and dexamethasone is a corticosteroid .
Bortezomib (Velcade) was approved in 2003. This was the first proteasome inhibitor approved for use in the U.S. Its boron atom binds the catalytic site of the 26S proteasome. [20] Carfilzomib (Kyprolis) was approved by the FDA for relapsed and refractory multiple myeloma in 2012 . [21]
Diazepam does not possess any chiral centers in its structure, but it does have two conformers.The two conformers mentioned were the 'P'-conformer and 'M'-conformer. Diazepam is an equimolar mixture and it was shown through CD spectra in serum protein solutions, that the 'P'-conformer is preferred by α1-acid glycoprotein b
Alprazolam is not very soluble in water; when crushed in water, it does not fully dissolve (40 μg/ml of H 2 O at pH 7). [125] There are also reports of alprazolam being snorted. [126] Due to the low weight of a dose, alprazolam, in one case, was distributed on blotter paper in a manner similar to LSD. [127]
1882 hand-colored map depicting the western half of the continental United States. This timeline of the American Old West is a chronologically ordered list of events significant to the development of the American West as a region of the continental United States.
Lorazepam was initially patented in 1963 and went on sale in the United States in 1977. [25] [26] It is on the World Health Organization's List of Essential Medicines. [27] It is available as a generic medication. [14] In 2022, it was the 80th most commonly prescribed medication in the United States, with more than 8 million prescriptions. [28 ...
France, [IX] officially the French Republic, [X] is a country located primarily in Western Europe. Its overseas regions and territories include French Guiana in South America, Saint Pierre and Miquelon in the North Atlantic, the French West Indies, and many islands in Oceania and the Indian Ocean, giving it one of the largest discontiguous exclusive economic zones in the world.